The story kicks off with a rafting trip that turns into a bloodbath for a group of college students, leaving only Alex (Janet Montgomery) alive. The narrative then shifts to a prison bus transporting dangerous convicts, led by the ruthless Carlos Chavez (Tamer Hassan). When the notorious cannibal runs the bus off a West Virginia road, the survivors—consisting of crooked cops and violent prisoners—must navigate the woods while being hunted.

One of the primary themes of "Wrong Turn 3: High Country" is the idea of survival in a hostile environment. The film takes place in a remote and isolated area, where the characters are forced to rely on their wits and resourcefulness to survive. The film also explores the theme of cannibalism, raising questions about the nature of humanity and the lengths to which people will go to survive.

Wrong Turn 3: Left for Dead (2009) is the best in the series critically (fans usually prefer parts 1, 2, or the 2021 reboot). But if you specifically want part 3 :