GTA V comes on two discs: a mandatory "Installation" disc and a "Play" disc. For the best performance, Rockstar recommends installing the mandatory installation disc to the internal Xbox 360 hard drive (or a USB drive) but running the "Play" disc directly from the optical drive. If you install both to the same USB drive, it can create a bandwidth bottleneck, resulting in texture pop-in issues.
However, you should still . High-quality USB 3.0 drives have much better internal flash controllers, meaning they will completely saturate the Xbox 360's USB 2.0 bandwidth, delivering the maximum possible speed the console can handle. Speed Ratings Matter install games xbox 360 usb best